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    Bacterial Genomes

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    Aswin Sai Narain Seshasayee, National Centre for Biological Sciences

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    Publisher: Open Book Publishers

    Language: English

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    CC BY-NC

    Table of Contents

    • Preface
    • All creatures great and small
    • The molecules of bacteria and of life
    • The genome: how much DNA?
    • The ebb and flow of bacterial genomes
    • Reading the organising the genome
    • Afterword
    • Index

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    About the Book

    Microbes form the “unseen majority” of life on Earth, with bacteria at the forefront as both the architects of life’s chemical foundations and agents of disease. But their story is far more complex. Bacteria thrive in diverse and extreme environments, driven by the dynamic evolution of their genomes. These tiny organisms wield an extraordinary ability to adapt, balancing genetic changes across generations with rapid physiological responses to environmental shifts.
     
    In Bacterial Genomes, the evolutionary and regulatory processes that shape bacterial life are brought to life. This textbook offers a conceptual exploration of how bacterial genomes are organized, how they evolve, and how their genetic information is interpreted through intricate molecular networks. Drawing on both cutting-edge research and the historical milestones that shaped microbiology, it illuminates how bacteria navigate the intersection of genetic adaptation and ecological resilience.
     
    Designed for college students, interdisciplinary researchers, and even the determined amateur, Aswin Seshasayee moves beyond technical jargon to provide a thought-provoking synthesis of bacterial evolution and adaptation. Unlike traditional genomics texts, this book blends historical insights with contemporary discoveries, offering a fresh perspective on the role of bacteria in shaping the living world.

    About the Contributors

    Author

    Aswin Sai Narain Seshasayee is a researcher and Associate Professor at the National Centre for Biological Sciences (NCBS), a centre of Tata Institute of Fundamental Research (TIFR) in Bangalore, India. His lab is interested in fundamental aspects of the function and evolution of bacterial genomes and gene regulatory networks. His career in the sciences started off with a Bachelors of Technology at Anna University, Chennai, India, during which a lot of time left alone to explore and break things in the bioinformatics laboratory of Professor Gautam Pennathur and in the experimental microbiology and protein engineering laboratory of Professor Sankaran encouraged him to take up research for a career. He then pursued research as an intern, a PhD student and then briefly a postdoc with Nicholas Luscombe at EMBL-European Bioinformatics Institute, Hinxton, Cambridge, UK (and St John’s College and Girton College, University of Cambridge). He has been with NCBS since December 2010, his research here funded over the years by the Department of Atomic Energy (Govt of India) core support to TIFR and NCBS, Department of Biotechnology, Department of Science and Technology and Science and Engineering Research Board (all Govt of India), CEFIPRA and DBT-Wellcome Trust India Alliance. Beyond science, he enjoys making music, painting watercolour landscapes and reading classic crime and fantasy fiction and popular history.

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